SaProtHub/DMS_BLAT_ECOLX

Base model: westlake-repl/SaProt_35M_AF2

Model Card for Model ID

This model is trained on a sigle site deep mutation scanning dataset and can be used to predict fitness score of mutant amino acid sequence of protein BLAT_ECOLX (Beta-lactamase TEM).

Protein Function

TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins.

Task type

protein level regression

Dataset description

The dataset is from Deep generative models of genetic variation capture the effects of mutations. And can also be found on SaprotHub dataset.

Label means fitness score of each mutant amino acid sequence, ranging from 0 to positive infinity where 1 is the value of wildtype, larger than 1 means higher fitness than wildtype.

Model input type

Amino acid sequence

Performance

0.80 Spearman's ρ

LoRA config

lora_dropout: 0.0

lora_alpha: 16

target_modules: ["query", "key", "value", "intermediate.dense", "output.dense"]

modules_to_save: ["classifier"]

Training config

class: AdamW

betas: (0.9, 0.98)

weight_decay: 0.01

learning rate: 1e-4

epoch: 50

batch size: 64

precision: 16-mixed